Our Mission

To develop novel strategies to reprogram the immunosuppressive tumor microenvironment (TME) toward an immunostimulatory transcriptional program in order to restore cytotoxicity T cell activation and sensitize tumors for cancer immunotherapy. We utilize state-of-the-art CyTOF, single-cell RNA sequencing, bioinformatics, computational modeling, tumor models and tumor organoids to investigate mechanisms of resistance and acquired resistance to immunotherapy.